Pharmacological Study Services for Autoimmune Inflammation

Pharmacological Study Services for Autoimmune Inflammation

BioMed Linkage collaborates with leading Chinese top-tier CROs to deliver comprehensive pharmacological study services tailored to autoimmune inflammation research. Our services focus on providing high-quality in vivo and in vitro data to support drug discovery, development, and regulatory submissions. Here’s how we can support your project:

1. Disease Models:
   • Access to validated small and large animal models mimicking autoimmune inflammation, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease (IBD), and systemic lupus erythematosus (SLE).
   • Models designed to assess the efficacy of drug candidates in modulating immune response and reducing inflammation.
2. Efficacy Studies:
   • Evaluation of therapeutic effects using biomarkers, histopathological analysis, and clinical scoring systems.
   • Cytokine profiling (e.g., TNF-α, IL-6, IL-17) to monitor immune modulation.
3. Mechanistic Studies:
   • Exploration of drug mechanisms of action, including effects on immune cell subsets (e.g., T-cells, B-cells, macrophages).
   • Pathway analysis of inflammatory signaling, such as NF-κB, JAK/STAT, or MAPK pathways.
4. Combination Therapy Evaluation:
   • Assessment of drug-drug interactions and combination therapies to enhance efficacy and reduce side effects.
5. Safety Pharmacology and Toxicology:
   • Comprehensive safety assessments, including immune-related adverse effects and off-target toxicity studies.
   • GLP-compliant safety pharmacology studies to support IND filings.
6. Advanced Techniques:
   • Multiparameter flow cytometry for immune profiling.
   • Transcriptomics, proteomics, and metabolomics to identify potential biomarkers and drug targets.
7. Tailored Study Design:
   • Customized protocols based on client needs, ensuring high relevance and translational potential to clinical applications.

BioMed Linkage ensures that your pharmacological studies for autoimmune inflammation are supported by cutting-edge techniques, high-quality data, and deep scientific expertise. Let us be your trusted partner in advancing therapeutics for autoimmune diseases.